General Information

  • ID:  hor000329
  • Uniprot ID:  NA
  • Protein name:  orcostatin I
  • Gene name:  NA
  • Organism:  Orconectes limosus
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SAGPYAFGL
  • Length:  9
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Exert dramatic inhibitory effects on contractions of the crayfish hindgut.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000329_AF2.pdbhor000329_ESM.pdb

Physical Information

Mass: 102486 Formula: C42H59N9O12
Absent amino acids: CDEHIKMNQRTVW Common amino acids: AG
pI: 6.09 Basic residues: 0
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: 63.33 Boman Index: 986
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 65.56
Instability Index: 3520 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  10477125
  • Title:  Structure, Distribution, and Biological Activity of Novel Members of the Allatostatin Family in the Crayfish Orconectes Limosus